JDRF, the type 1 diabetes charityResearch ProjectsWhat conditions are best for growing beta cells from stem cells?

What conditions are best for growing beta cells from stem cells?

JDRF researcher Rocio Sancho and members of her group in a lab

Scientific title: PEG-based hydrogels for iPSCs-derived regenerative therapies for diabetes
Principal investigator: Dr Rocio Sancho
Institution: King’s College London
Duration of award: 01 November 2019 – 31 October 2022

Overview

This project is looking at a new way to turn stem cells into beta cells in the lab, to better understand what conditions make this process happen efficiently.

The team will also run tests to see if the cells grown using this technique can be transplanted safely into mice, and produce insulin on demand.

The research could support researchers who need beta cells for their research, and could one day offer a way to generate beta cells for transplanting into people with type 1.

How will this research help people with type 1?

Knowing what conditions might allow large numbers of beta cells to be grown from stem cells should make it easier to do research on beta cells. This would give us a much better understanding of type 1 diabetes and how it could be treated.

The research could also make it easier to replace the lost beta cells in people with type 1, by giving us a sustainable source of replacement cells.

Combined with a treatment to stop the immune system’s attack on beta cells, this could allow people with type 1 to once again produce their own insulin and reduce or avoid the need for injections.

Is JDRF funding any other research like this?

In the UK, JDRF funded Dr Francesca Spagnoli (also at King’s College London) to find out how to grow beta-like cells from skin cells.

In the US, we fund Professor Doug Melton at Harvard University and Dr Jeffrey Millman at the Washington University in St Louis, who are both looking at growing large numbers of beta cells in the lab, so that they can be used for research and new treatments.