Scientific title: Investigating the effects of ultra-low dose IL-2 on the modulation of the peripheral immune system at a single-cell level
Principle Investigator: Professor John Todd
Institution: University of Oxford
Duration of award: October 2018 – March 2021
Previous work has found that the molecule IL-2 plays an important role in regulating the immune system, and that reduced levels of IL-2 are linked to the development of type 1 diabetes.
JDRF has previously funded the team to explore a potential treatment for type 1 diabetes based on giving IL-2. The team have recently completed studies that showed that treatment with IL-2 is safe and is able to increase the number of “good” immune cells that protect the pancreas.
This particular project will help the team to understand the precise effects of IL-2 treatment on the activity of different types of immune cells. This will help the team understand how the IL-2 treatment works, and spot whether there are any off-target side-effects that need to be addressed.
Click on the image below to download a poster about Professor Todd’s project.