Why do some people continue to make insulin after diagnosis?

Andrew Hattersley
Andrew Hattersley

Scientific title: Potential mechanisms of persistent C-peptide in Type 1 diabetes
Principal Investigator: Professor Andrew Hattersley
Institution: University of Exeter
Project duration: 01/10/2014 – 30/09/2017

Objective: Type 1 diabetes occurs when the immune system destroys the body’s insulin-producing beta cells. However, some people continue to produce trace levels of insulin for years after diagnosis. While these levels aren’t high enough to avoid the need for insulin injections, the people who have them tend to experience fewer complications later in life. This study is looking at what sets these people apart, in terms of their immune systems, to allow them to continue to produce insulin. Knowing this could lead to ways to encourage this protection in others, helping to preserve their insulin production, and reducing their chance of developing complications.

Categories: Cure, Strategic Research Agreement, Immune Therapies