Injections to teach the immune system not to attack beta cells – COMPLETED
Scientific title: MonoPepT1De trial
Principal Investigators: Professors Colin Dayan and Mark Peakman
Institutions: Cardiff University and King’s College London
Project duration: 01/08/2014 – 31/01/2017
Objective: Professors Dayan and Peakman and their teams want to find out if we can teach the immune system to stop attacking the insulin-producing cells in the pancreas.
They are giving participants small fragments of the insulin precursor molecule, as they think this should make the immune system more tolerant to the cells that make insulin. The process is effectively a ‘reverse vaccination’ as it is training the immune system to tolerate something.
The trial is a follow-up to a previous study, also called MonoPepT1De, that looked at using a smaller number of injections, and only in people who had had type 1 for many years.
Categories: Cure, Prevent, Strategic Research Agreement, Immune Therapies