Injections to teach the immune system not to attack beta cells – COMPLETED

Colin Dayan
Colin Dayan

Scientific title: MonoPepT1De trial
Principal Investigators: Professors Colin Dayan and Mark Peakman
Institutions: Cardiff University and King’s College London
Project duration: 01/08/2014 – 31/01/2017

Objective:  Professors Dayan and Peakman and their teams want to find out if we can teach the immune system to stop attacking the insulin-producing cells in the pancreas.

Mark Peakman
Mark Peakman

They are giving participants small fragments of the insulin precursor molecule, as they think this should make the immune system more tolerant to the cells that make insulin. The process is effectively a ‘reverse vaccination’ as it is training the immune system to tolerate something.

The trial is a follow-up to a previous study, also called MonoPepT1De, that looked at using a smaller number of injections, and only in people who had had type 1 for many years.

You can read more about the trial, and how to take part, in our ‘How to get involved’ section.

Categories: Cure, Prevent, Strategic Research Agreement, Immune Therapies