Skip to main content

Sanofi and Provention Bio partner to support potential launch of drug to delay type 1

The global healthcare company Sanofi has partnered with the developers of teplizumab, Provention Bio, to expand the worldwide reach and awareness of the new immunotherapy drug.
JDRF logo placeholder for author profile picture
Mary-Liz McGrath 10 October 2022

A researcher holding an injection

Olivier Bogillot, Head of US General Medicines at Sanofi, said: “We are delighted by the prospect of supporting Provention Bio in bringing to the US what could become the first-in-class therapy to change the course of type 1 diabetes. If approved, Sanofi US will leverage its existing world-class capabilities in diabetes care to enhance efforts in both patient and healthcare provider access. We are prepared to tap into all of our internal expertise to support the successful launch of this innovative therapy.”

While Ashleigh Palmer, Co-Founder and Chief Executive Officer at Provention Bio, added: “We look forward to working with our colleagues at Sanofi as we prepare to deliver, if approved, the first-ever disease-modifying therapy for T1D.”

What is teplizumab?

Teplizumab is a promising immunotherapy drug that can protect insulin-producing beta cells from the immune attack that causes type 1 diabetes. It does this by targeting the aggressive immune cells to disarm and kill them.

In doing so, the exciting new drug led to an average three-year delay in the onset of type 1 for people at most risk. This means giving a pre-diabetes patient an extra three years with a functioning pancreas. This remarkable effect is achieved after just 14 days of injections of teplizumab.

Awaiting approval in the US

Teplizumab is currently under review by the US Food and Drug Administration (FDA) after Provention Bio submitted more evidence in favour of its effectiveness. Sanofi has pledged to invest further in Provention Bio if the FDA does approve teplizumab.

The FDA is expected to announce its decision whether to approve the use of teplizumab in the US later in November.

How will this impact the UK?

If the FDA approves teplizumab it will likely influence the decision of international agencies like the Medicines and Healthcare products Regulatory Agency (MHRA), which authorises drugs in the UK.

In summer 2021, teplizimuab was awarded an Innovation Passport by the MHRA. This means that the MHRA has been working closely with Provention Bio to drive teplizimuab towards becoming a licensed treatment in the UK to delay type 1 in those at most risk.

Pivotal role by JDRF

The Innovation Passport and the fast-track it provides was made possible by robust evidence provided by JDRF-funded clinical trials. We are now funding clinical trials as part of the Type 1 Diabetes UK Immunotherapy Consortium to see if teplizumab can also slow the disease progression in people who already have type 1.

Related news

Read more
A row of vials of clear liquid with black lids. A blue gloved hand is pinching the top of the closest vial as if to pick it up.
13 May 2024

Novel insulin being developed to enable implantable insulin pumps

Medtronic Diabetes have announced they are funding the biopharmaceutical company Arecor Therapeutics to develop a novel, highly concentrated, thermostable insulin, which will be specialised for use in implantable insulin pumps.

Read more
Professor Colin Dayan at Cardiff University, working on immunotherapy for type 1 diabetes cure research
Research
18 April 2024

Professor Colin Dayan presented with the 2023 JDRF Rumbough Award 

The award recognises Professor Dayan’s remarkable accomplishments in type 1 diabetes research.

Read more
Professor Richard Oram in the Research, Innovation, Learning and Development (RILD) building at the University of Exeter.
7 March 2024

New biochip launches that detects genetic risk of type 1 diabetes

A new test by Randox, developed with JDRF-funded researchers at the University of Exeter, is the first in the world to use genetics to quickly identify who is at high risk of developing type 1 diabetes.

Read more
A graphic of a DNA double helix with a piece being removed demonstrating genetic engineering.
Cure research
21 February 2024

Primate with type 1 diabetes becomes insulin-independent after receiving gene-edited cells without immunosuppression

A transplant of stem cells grown into pancreatic islets has allowed a primate with type 1 to make its own insulin again.