Landmark drug trial could revolutionise future treatment for type 1 diabetes

Posted on 18 November 2019

Professor John Petrie, University of Glasgow
Professor John Petrie is leading the TTT1 trial at the University of Glasgow

JDRF-funded researchers from the University of Glasgow are eagerly anticipating the start of a pioneering new global trial, described as “the single most advanced drug-based study to date in type 1 diabetes.”

The TTT1 trial – funded by JDRF, and co-led by State University of New York – aims to help people with type 1 diabetes who still struggle to manage their blood glucose levels, despite improvements in technology including insulin pumps and continuous glucose monitoring (CGM).

The TTT1 trial is led by the University of Glasgow’s global leader in the treatment of type 1 diabetes, Professor John Petrie. The trial aims to address a gap in current treatment, which sees a majority of people on insulin therapy with an HbA1c above the recommended target of 7%, indicating high blood glucose over the previous two to three months.

The trial will assess a new combination therapy of insulin and two drugs called dapagliflozin and semaglutide.

Dapagliflozin, as well as a drug related to semaglutide called liraglutide, can improve blood glucose management in adults with type 1 diabetes. Dapagliflozin has recently been approved for this purpose in the UK and Europe, but neither drug alone consistently gets most people with type 1 diabetes to the recommended target HbA1c.

Improved quality of life

Professor Petrie said: “The hope is to use the combination therapy of dapagliflozin and semaglutide to reduce HbA1c to less than 7% in the majority of people with type 1 diabetes.

“And since these drugs have benefits for the heart and can also induce weight loss, there may be additional advantages of this drug combination, which would be very positive for those with the condition.

“In addition, both dapagliflozin and semaglutide are likely to reduce unpredictable fluctuations in blood glucose levels, thus providing a greater sense of security for people with type 1 diabetes, substantially improving their quality of life.”

Rachel Connor, Director of Research Partnerships at JDRF, said: “Type 1 diabetes is a really challenging condition to manage, and the limitations of the tools we have today, both technologies and medicines, mean that many people living with the condition struggle to achieve the glucose management targets recommended by doctors.

“We’re proud to support the TTT1 trial and are hopeful that this will lead to a new way to help people with type 1 reduce HbA1c and so also reduce their risk of developing long-term complications.”

You can read more about the trial on the NIH Clinical Trials website.

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