Breakthrough JDRF-funded artificial pancreas study welcomed as new data reveals people with type 1 diabetes average ten hypos a week

Posted on 22 April 2014

In a world first, British children with type 1 diabetes have successfully been entrusted to use pioneering artificial pancreas technology all by themselves at home overnight – without the careful supervision of expert researchers. Celebrities that live with the condition, including Hollywood actor Jeremy Irvine, have hailed the findings.news_domlittlewood3

The latest trial, coordinated by the University of Cambridge and funded solely by JDRF, has shown for the first time globally that unsupervised use of the artificial pancreas overnight can be safe – while also providing exciting benefits.

Participants, all aged between 12 and 18, saw improved blood glucose control during the trial and experienced fewer nights with hypoglycaemic episodes.

The breakthrough trial, detailed in the journal Diabetes Care, comes as JDRF reveals UK people living with the condition are experiencing a “shockingly high” average of ten hypos a week – laying bare the urgent need for the artificial pancreas to become an accessible reality.

The figure of ten hypos per week has emerged through a first ever real-time information haul of more than 10,000 UK residents with type 1 diabetes, released to JDRF from the popular mySugr app. It follows the recent revelation that nine per cent of all hospital admissions for children and young people with diabetes are due to hypos.

All previous artificial pancreas trials, in hospitals and in home environments, have seen researchers strictly monitor patients. News of the successful unsupervised trial has had a positive response from UK celebrities that live with type 1 diabetes.

Hollywood actor Jeremy Irvine, who is a JDRF supporter, has lived with type 1 diabetes since the age of six. He said: ‘When the chance came for me to take part in early artificial pancreas trials a few years ago, I jumped at the opportunity. I wanted to play my own very small part in moving the artificial pancreas closer to reality. I’m really excited to hear of this latest progress – the scientists behind it are my heroes.’

Television presenter Dominic Littlewood gave his reaction to the statistic showing that UK people with type 1 diabetes are having 10 hypos a week. He said: ‘I have lived with type 1 diabetes for almost 40 years. When you do the maths, 10 per week means I may have had 20,000 hypos in my lifetime. That’s more than many people have had hot dinners. It highlights the challenge that this life-long condition represents.’

He added: “Worrying about hypos – let alone actually having one – is a daily stress for anyone with this condition. I experienced my worst hypo during the night in a hotel room just over 10 years ago. I found myself crawling along my hotel room floor, before finally being hospitalised. It nearly killed me. That’s why JDRF’s progress on the artificial pancreas means a lot to me.”

Sky News presenter Stephen Dixon, who was diagnosed with type 1 diabetes when he was 17, said: ‘I’ve always refused to let type 1 diabetes hold me back. But minimising hypos does take considerable effort. I always carry Glucogel or a snack around with me in case I feel the symptoms of a hypo come on – which has happened when I’ve been on air. The artificial pancreas is very exciting technology. I look forward to the time when I can use one myself as part of day-to-day life.’

Dr Roman Hovorka from the University of Cambridge is leading the UK effort to develop an effective artificial pancreas. As principal researcher on the trial, he said: “The study is an important stepping stone for the wider use of an artificial pancreas. We have shown that overnight home use is feasible and beneficial – allowing people to live their life more freely.”

He added: ‘The artificial pancreas is expected to transform the treatment of type 1 diabetes and we have proven that this promise holds. The success of this trial means that larger and longer studies are already in the pipeline.’

Professor Katharine Barnard, from the Human Development and Health Academic Unit at the University of Southampton, worked with Dr Hovorka on the trial to evaluate psychosocial impact. She said: ‘Hypoglycaemia – particularly at night – is a common fear among those living with type 1 diabetes and a major obstacle in achieving optimal blood glucose levels. The findings from this study are positive and are certainly worth investigating further.’

She added: ‘Reassurance, confidence and improved diabetes control are just some of the psychological and physical benefits that patients may witness as artificial pancreas technology continues to develop.’

Karen Addington, Chief Executive of JDRF, said: ‘Type 1 diabetes is a challenging and complex condition that requires constant management every day. Hypos are what people living with type 1 diabetes hate the most and experiencing ten a week is a shockingly high figure.’

She added: ‘This particular research was funded solely by JDRF – but we salute the commitment of other organisations around the world who work with us, including Diabetes UK, which are also dedicated to making the artificial pancreas a reality. Continued collaboration is crucial until we find the cure.’

 * From the Royal College of Paediatrics and Child Health (RCPCH)’s audit. The nine per cent figure is for England and Wales. The full audit can be accessed online.